Chronic Fatigue Syndrome (ME/CFS)
A complex disorder marked by extreme, unexplained, and persistent fatigue.
Definition
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, long-term illness defined by profound fatigue that is not relieved by rest and worsens after physical or mental exertion. It often includes cognitive difficulties, unrefreshing sleep, and dizziness. As an invisible illness, it is frequently misunderstood and underdiagnosed.
The Diagnostic Journey
A typical path patients take with Chronic Fatigue Syndrome (ME/CFS) — from first symptoms to living with the condition. Click each stage to expand.
Many invisible illnesses begin with vague, intermittent symptoms such as fatigue, pain, or changes in weight or mood. Because these signs are non-specific and can come and go, they are frequently attributed to stress or overwork, which is one reason diagnosis is so often delayed.
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Sources & References
This page draws on trusted, authoritative health resources. For medical decisions, always consult a qualified healthcare professional.
- FatigueMedlinePlus, U.S. National Library of MedicineGovernment Health Agency
- Autoimmune DiseasesMedlinePlus, U.S. National Library of MedicineGovernment Health Agency
- Coping with Chronic IllnessMedlinePlus, U.S. National Library of MedicineGovernment Health Agency
- Health Topics: Trusted Consumer Health InformationMedlinePlus, U.S. National Library of MedicineGovernment Health Agency
- Health Topics A-ZMedlinePlus, U.S. National Library of MedicineGovernment Health Agency
- Health Library: Diseases & ConditionsCleveland ClinicAcademic Medical Center
Content Review
- Last Reviewed
- July 2026
- Last Updated
- July 2026
- Content Type
- Educational Documentary Companion
- Evidence Standard
- Evidence-Informed
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