Differential Diagnosis
The process of distinguishing a condition from others with similar symptoms.
Definition
Differential diagnosis is the systematic method physicians use to identify a disease by weighing the probability of several conditions that could cause a patient's symptoms. It involves gathering history, examination findings, and test results to rule conditions in or out. It is considered both a science and a clinical art.
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Sources & References
This page draws on trusted, authoritative health resources. For medical decisions, always consult a qualified healthcare professional.
- Diagnostic TestsMedlinePlus, U.S. National Library of MedicineGovernment Health Agency
- Improving Diagnosis in Health CareNational Academies of Sciences, Engineering, and MedicinePeer-Reviewed Resource
- Patient Engagement & Hormone HealthEndocrine SocietyProfessional Medical Society
- Health InformationNational Institutes of Health (NIH)Government Health Agency
- Health Topics: Trusted Consumer Health InformationMedlinePlus, U.S. National Library of MedicineGovernment Health Agency
- Health Topics A-ZMedlinePlus, U.S. National Library of MedicineGovernment Health Agency
- Health Library: Diseases & ConditionsCleveland ClinicAcademic Medical Center
Content Review
- Last Reviewed
- July 2026
- Last Updated
- July 2026
- Content Type
- Educational Documentary Companion
- Evidence Standard
- Evidence-Informed
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